Platelet influence on the development and progression of cardiovascular disease (CVD) is well established, especially in atherosclerosis and acute thrombotic events. However, this sensitivity can also result in a hyperaggregable state, in which circulating platelets become chronically sensitised by stress signals from the blood and vascular endothelium, and in these circumstances platelets can also contribute to pathologic processes. Platelets play a key role in blood homeostasis their responsiveness to a diverse range of external stimuli allows them to respond to vascular stress and helps to preserve the integrity of the vascular system. It may be pertinent to personalize the daily intake of Fruitflow® depending on individual platelet response. The data suggest that the efficacious range for Fruitflow® lies between 75 mg and 300 mg, depending on the individual. Effects observed for 0 mg and 30 mg supplements were non-equivalent to 150 mg and not different from baseline (aggregation changed by 3.0 ± 5.0% and − 0.7 ± 10.2% respectively, while thrombin generation changed by 0.8 ± 3.0% and 0.8 ± 3.1% respectively). Results showed that the changes from baseline aggregation and thrombin generation observed after the 75 mg, 150 mg, and 300 mg supplements were equivalent. Results were evaluated for equivalence to the standard 150 mg dose. Platelet response to adenosine diphosphate (ADP) agonist and thrombin generation capacity were monitored at baseline and 24 h after consuming 0, 30, 75, 150 or 300 mg of Fruitflow® in a randomized, double-blinded crossover study in male subjects 30–65 years of age ( N = 12). We carried out a pilot study to investigate the range of intakes linked to efficacy and to make an initial assessment of variability in response to Fruitflow®.

The water-soluble tomato extract, Fruitflow® is a dietary antiplatelet which can be used to lower platelet aggregability in primary preventative settings.

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